Case Studies
Research examples and validation studies
Overview
This section presents case studies demonstrating how EuTxGNN predictions have been validated against clinical evidence.
Featured Case Studies
Case Study 1: Metformin for PCOS
Drug: Metformin (DB00331) Predicted Indication: Polycystic Ovary Syndrome TxGNN Score: 0.9987 Evidence Level: L2
Background
Metformin is a first-line treatment for type 2 diabetes. EuTxGNN identified PCOS as a strong repurposing candidate.
Validation
| Source | Findings |
|---|---|
| ClinicalTrials.gov | 45+ registered trials |
| PubMed | 500+ publications |
| Clinical Use | Widely used off-label |
Outcome
✅ Validated - Metformin is now recognized as a treatment option for PCOS with insulin resistance.
Case Study 2: Ibuprofen for Alzheimer’s
Drug: Ibuprofen (DB01050) Predicted Indication: Alzheimer’s Disease TxGNN Score: 0.9854 Evidence Level: L3
Background
NSAIDs like ibuprofen have been hypothesized to reduce neuroinflammation.
Validation
| Source | Findings |
|---|---|
| ClinicalTrials.gov | 8 registered trials |
| PubMed | 200+ publications |
| Clinical Status | Under investigation |
Outcome
🔄 Promising but inconclusive - Observational studies suggest potential benefit, but RCTs have shown mixed results.
Case Study 3: Thalidomide for Multiple Myeloma
Drug: Thalidomide (DB01041) Predicted Indication: Multiple Myeloma TxGNN Score: 0.9991 Evidence Level: L1
Background
Originally withdrawn due to teratogenicity, thalidomide was later found to have anti-cancer properties.
Validation
| Source | Findings |
|---|---|
| ClinicalTrials.gov | 150+ registered trials |
| FDA Approval | Yes (1998) |
| EMA Approval | Yes |
Outcome
✅ Validated and approved - Now a standard treatment for multiple myeloma.
Evidence Level Distribution
| Outcome | L1-L2 | L3-L4 | L5 |
|---|---|---|---|
| Validated | 85% | 35% | 5% |
| Promising | 10% | 45% | 25% |
| No evidence | 5% | 20% | 70% |
How to Conduct Your Own Case Study
Step 1: Select a Prediction
- Browse High Evidence Drugs
- Select a drug-indication pair of interest
- Note the TxGNN score and evidence level
Step 2: Gather Evidence
- Search ClinicalTrials.gov
- Search PubMed
- Check regulatory databases (FDA, EMA)
Step 3: Analyze Results
- Count relevant trials by phase
- Review publication quality
- Assess clinical adoption
Step 4: Document Findings
- Record all sources
- Note limitations
- Share via GitHub Issues
Contributing
We welcome case study contributions from the research community.
Submission Guidelines
- Use the case study template
- Include all evidence sources
- Provide objective analysis