Drug-Drug Interactions (DDI)
Comprehensive DDI data for drug repurposing safety evaluation
Introduction
Drug-drug interactions are a critical consideration in drug repurposing. When a drug is considered for a new indication, it may be used alongside different medications than originally intended, potentially creating new interaction risks.
Data Sources
| Source | Records | Drugs | Last Updated |
|---|---|---|---|
| DDInter 2.0 | ~190,000 | 1,833 | 2023 |
| Guide to PHARMACOLOGY | ~32,000 | 477 | 2024 |
Severity Classification
| Level | Description | Action |
|---|---|---|
| Major | Potentially life-threatening | Avoid combination |
| Moderate | May require monitoring | Use with caution |
| Minor | Generally safe | Monitor if necessary |
Usage
DDI information is integrated into individual drug reports. For each drug in EuTxGNN:
- Navigate to the drug report page
- Check the “Safety Considerations” section
- Review major and moderate interactions
External Resources
- DDInter 2.0 - Drug-Drug Interaction database
- DrugBank Interactions - Commercial drug database
- Drugs.com Interaction Checker - Consumer resource
Data Download
DDI datasets are available for research use: