Drug-Disease Interactions (DDSI)
Drug-disease contraindication and precaution data
Introduction
Drug-disease interactions occur when a medication may worsen an existing medical condition. This is especially important in drug repurposing, where the target patient population may have different comorbidities than the original indication.
Severity Classification
| Level | Description | Example |
|---|---|---|
| Contraindicated | Should not be used | Beta-blockers in severe asthma |
| Moderate | Use with caution | NSAIDs in kidney disease |
| Minor | Monitor recommended | Statins in liver disease |
Common Categories
Cardiovascular Conditions
- Heart failure
- Arrhythmias
- Hypertension
Renal/Hepatic
- Kidney disease
- Liver impairment
Neurological
- Seizure disorders
- Parkinson’s disease
Metabolic
- Diabetes
- Thyroid disorders
Usage in Drug Reports
Each drug report includes relevant DDSI warnings in the safety section, helping researchers identify contraindications for the proposed new indication.