Amlodipine

Evidence Level: L5 Predicted Indications: 50

Quick Overview

Item Value
Drug Name Amlodipine
DrugBank ID DB00381
Brand Names (EU) Amlodipine
Evidence Level L5
Predicted Indications 50
Top Prediction Score 99.97%

Approved Indication (EMA)

Treatment of essential hypertension in adults: Add-on therapy Twynsta is indicated in adults whose blood pressure is not adequately controlled on amlodipine. Replacement therapy Adult patients receiving telmisartan and amlodipine from separate tablets can instead receive tablets of Twynsta containing the same component doses.

Predicted New Indications

TxGNN model predictions for potential drug repurposing:

Rank Indication Score Source
1 obsolete susceptibility to ischemic stroke 99.97% DL
2 cerebrovascular disorder 99.96% DL
3 brain stem infarction 99.94% DL
4 Prinzmetal angina 99.94% DL
5 cerebral infarction 99.91% DL
6 pulmonary hypertension with unclear multifactorial mechanism 99.91% DL
7 pulmonary hypertension owing to lung disease and/or hypoxia 99.91% DL
8 malignant renovascular hypertension 99.90% DL
9 malignant hypertensive renal disease 99.90% DL
10 hypertensive disorder 99.89% DL
11 cerebral artery occlusion 99.89% DL
12 Braddock syndrome 99.88% DL
13 stroke disorder 99.88% DL
14 MRI defined brain infarct 99.86% DL
15 ABri amyloidosis 99.84% DL
16 intracerebral hemorrhage 99.79% DL
17 cerebral arterial disease 99.78% DL
18 chronic pulmonary heart disease 99.69% DL
19 spinal cord ischemia 99.65% DL
20 cholesterol embolism 98.56% DL

Showing top 20 of 50 predictions.

About TxGNN Predictions

Prediction Sources

Source Description
KG Knowledge Graph - Network topology-based associations
DL Deep Learning - Neural network score prediction

Evidence Levels

Level Definition
L1 Multiple Phase 3 RCTs / Systematic Reviews
L2 Single RCT or multiple Phase 2 trials
L3 Observational studies / Large case series
L4 Preclinical / Mechanistic / Case reports
L5 AI prediction only (current)

Clinical Validation Needed

Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.

Next Steps for Validation

  1. Literature Review: Search PubMed for existing evidence
  2. Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
  3. Mechanistic Analysis: Evaluate biological plausibility
  4. Preclinical Studies: Conduct in vitro/in vivo validation
  5. Clinical Trials: Design and conduct human studies

Data Access

Citation

If using this data, please cite:

@article{huang2023txgnn,
  title={A foundation model for clinician-centered drug repurposing},
  author={Huang, Kexin and others},
  journal={Nature Medicine},
  year={2023},
  doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.

Copyright © 2026 EuTxGNN Project. For research purposes only. Not medical advice.