Belatacept
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Belatacept |
| DrugBank ID | DB06681 |
| Brand Names (EU) | Nulojix |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 97.03% |
Approved Indication (EMA)
Nulojix, in combination with corticosteroids and a mycophenolic acid (MPA), is indicated for prophylaxis of graft rejection in adult recipients of a renal transplant.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | plasma cell myeloma | 97.03% | DL |
| 2 | indolent plasma cell myeloma | 96.94% | DL |
| 3 | relapsing-remitting multiple sclerosis | 96.82% | DL |
| 4 | Crohn’s colitis | 96.18% | DL |
| 5 | heart disease | 94.62% | DL |
| 6 | Laubry-Pezzi syndrome | 94.06% | DL |
| 7 | hyperthyroidism | 93.81% | DL |
| 8 | genetic syndromic Pierre Robin syndrome | 93.71% | DL |
| 9 | Pierre Robin syndrome associated with a chromosomal anomaly | 93.66% | DL |
| 10 | colonic neoplasm | 93.63% | DL |
| 11 | Jeune syndrome situs inversus | 93.53% | DL |
| 12 | orofacial clefting syndrome | 93.51% | DL |
| 13 | disorder of fucoglycosan synthesis | 93.42% | DL |
| 14 | partial deletion of the long arm of chromosome 7 | 93.31% | DL |
| 15 | pulmonary valve disease | 93.03% | DL |
| 16 | primary release disorder of platelets | 92.99% | DL |
| 17 | psoriasis | 92.97% | DL |
| 18 | interventricular septum aneurysm | 92.96% | DL |
| 19 | partial deletion of the long arm of chromosome 22 | 92.94% | DL |
| 20 | resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta | 92.73% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.