Bezlotoxumab
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Bezlotoxumab |
| DrugBank ID | DB13140 |
| Brand Names (EU) | Zinplava |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.89% |
Approved Indication (EMA)
Zinplava is indicated for the prevention of recurrence of Clostridium difficile infection (CDI) in adults at high risk for recurrence of CDI.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | acute female pelvic peritonitis | 99.89% | DL |
| 2 | embryonic cyst of fallopian tube | 99.89% | DL |
| 3 | tubal pregnancy | 99.89% | DL |
| 4 | salpingitis isthmica nodosa | 99.88% | DL |
| 5 | disease of uterine broad ligament | 99.87% | DL |
| 6 | lumbar spinal stenosis | 99.87% | DL |
| 7 | celiac trunk compression syndrome | 99.87% | DL |
| 8 | abdominal cystic lymphangioma | 99.87% | DL |
| 9 | abdominal ectopic pregnancy | 99.87% | DL |
| 10 | pelvic varices | 99.87% | DL |
| 11 | lymph node palisaded myofibroblastoma | 99.87% | DL |
| 12 | disease of retroperitoneum | 99.87% | DL |
| 13 | sacrum chordoma | 99.87% | DL |
| 14 | disease of peritoneum | 99.87% | DL |
| 15 | urethral disease | 99.87% | DL |
| 16 | pudendal neuralgia | 99.83% | DL |
| 17 | bronchial adenomas/carcinoids childhood | 99.80% | DL |
| 18 | non-seminomatous lesion | 99.80% | DL |
| 19 | ductal or ductular proliferation | 99.80% | DL |
| 20 | chondroid hamartoma | 99.80% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.