Cholic Acid

Evidence Level: L5 Predicted Indications: 56

Quick Overview

Item Value
Drug Name Cholic Acid
DrugBank ID DB02659
Brand Names (EU) Orphacol
Evidence Level L5
Predicted Indications 56
Top Prediction Score 99.89%

Approved Indication (EMA)

Orphacol is indicated for the treatment of inborn errors in primary bile acid synthesis due to3β-Hydroxy-Δ5-C27-steroid oxidoreductase deficiency or Δ4-3-Oxosteroid-5β-reductase deficiency ininfants, children and adolescents aged 1 month to 18 years and adults.

Predicted New Indications

TxGNN model predictions for potential drug repurposing:

Rank Indication Score Source
1 cholelithiasis 99.89% DL
2 HIV infectious disease 99.79% DL
3 obsolete familial combined hyperlipidemia 99.78% DL
4 homozygous familial hypercholesterolemia 99.75% DL
5 biotin metabolic disease 99.74% DL
6 vitamin deficiency disorder 99.71% DL
7 hereditary hemochromatosis 99.69% DL
8 neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter 99.66% DL
9 hemosiderosis 99.65% DL
10 disorder of phenylalanine metabolism 99.61% DL
11 bone Paget disease 99.60% DL
12 inborn error of biotin metabolism 99.56% DL
13 feline acquired immunodeficiency syndrome 99.56% DL
14 simian immunodeficiency virus infection 99.56% DL
15 obsolete rare hereditary hemochromatosis 99.52% DL
16 hyperphenylalaninemia due to tetrahydrobiopterin deficiency 99.51% DL
17 inborn disorder of pyridoxine metabolism 99.46% DL
18 Wilson disease 99.44% DL
19 constitutional megaloblastic anemia due to folate metabolism disorder 99.43% DL
20 cerebral folate deficiency 99.42% DL

Showing top 20 of 56 predictions.

About TxGNN Predictions

Prediction Sources

Source Description
KG Knowledge Graph - Network topology-based associations
DL Deep Learning - Neural network score prediction

Evidence Levels

Level Definition
L1 Multiple Phase 3 RCTs / Systematic Reviews
L2 Single RCT or multiple Phase 2 trials
L3 Observational studies / Large case series
L4 Preclinical / Mechanistic / Case reports
L5 AI prediction only (current)

Clinical Validation Needed

Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.

Next Steps for Validation

  1. Literature Review: Search PubMed for existing evidence
  2. Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
  3. Mechanistic Analysis: Evaluate biological plausibility
  4. Preclinical Studies: Conduct in vitro/in vivo validation
  5. Clinical Trials: Design and conduct human studies

Data Access

Citation

If using this data, please cite:

@article{huang2023txgnn,
  title={A foundation model for clinician-centered drug repurposing},
  author={Huang, Kexin and others},
  journal={Nature Medicine},
  year={2023},
  doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.

Copyright © 2026 EuTxGNN Project. For research purposes only. Not medical advice.