Dostarlimab
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Dostarlimab |
| DrugBank ID | DB15627 |
| Brand Names (EU) | Jemperli |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 50.00% |
Approved Indication (EMA)
Jemperli is indicated in combination with carboplatin and paclitaxel for the first-line treatment of adult patients with primary advanced or recurrent endometrial cancer (EC) and who are candidates for systemic therapy. Jemperli is indicated as monotherapy for the treatment of adult patients with mismatch repair deficient (dMMR)/ microsatellite instability‑high (MSI‑H) recurrent or advanced EC that has progressed on or following prior treatment with a platinum‑containing regimen.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | rod-cone dystrophy, sensorineural deafness, and Fanconi-type renal dysfunction | 50.00% | DL |
| 2 | immune epilepsy | 50.00% | DL |
| 3 | myoclonic encephalopathy in non-progressive disorder | 50.00% | DL |
| 4 | self-limited familial and non-familial neonatal/infantile seizures | 50.00% | DL |
| 5 | photosensitive occipital lobe epilepsy | 50.00% | DL |
| 6 | adult-onset segmental dystonia | 50.00% | DL |
| 7 | autoimmune retinopathy | 50.00% | DL |
| 8 | paratenonitis with tendinosis | 50.00% | DL |
| 9 | idiopathic anaphylaxis | 50.00% | DL |
| 10 | acetazolamide-responsive hereditary episodic ataxia | 50.00% | DL |
| 11 | saccharopinuria | 50.00% | DL |
| 12 | EEC syndrome | 50.00% | DL |
| 13 | complex neurodevelopmental disorder | 50.00% | DL |
| 14 | structural epilepsy | 50.00% | DL |
| 15 | metabolic epilepsy | 50.00% | DL |
| 16 | TH-deficient infantile parkinsonism and motor delay | 50.00% | DL |
| 17 | PRPS1 deficiency disorder | 50.00% | DL |
| 18 | food-dependent exercise-induced anaphylaxis | 50.00% | DL |
| 19 | paratenonitis | 50.00% | DL |
| 20 | adolescent/adult-onset epilepsy syndrome | 50.00% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.