Duloxetine Hydrochloride
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Duloxetine Hydrochloride |
| DrugBank ID | DB00476 |
| Brand Names (EU) | Yentreve |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.94% |
Approved Indication (EMA)
Yentreve is indicated for women for the treatment of moderate to severe stress urinary incontinence (SUI).
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | endogenous depression | 99.94% | DL |
| 2 | major depressive disorder | 99.92% | DL |
| 3 | anxiety disorder | 99.91% | DL |
| 4 | benign paroxysmal torticollis of infancy | 99.85% | DL |
| 5 | agoraphobia | 99.84% | DL |
| 6 | obsessive-compulsive disorder | 99.84% | DL |
| 7 | unipolar depression | 99.83% | DL |
| 8 | histrionic personality disorder (disease) | 99.78% | DL |
| 9 | schizoid personality disorder | 99.78% | DL |
| 10 | paranoid personality disorder | 99.78% | DL |
| 11 | schizotypal personality disorder | 99.78% | DL |
| 12 | Ohdo syndrome and variants | 99.69% | DL |
| 13 | ligneous conjunctivitis | 99.66% | DL |
| 14 | blepharophimosis - intellectual disability syndrome, Ohdo type | 99.60% | DL |
| 15 | dysthymic disorder | 99.52% | DL |
| 16 | melancholia | 99.43% | DL |
| 17 | neurotic depression | 99.41% | DL |
| 18 | myofascial pain syndrome | 99.38% | DL |
| 19 | phobic disorder | 99.38% | DL |
| 20 | childhood apraxia of speech | 99.21% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.