Ferric Maltol
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Ferric Maltol |
| DrugBank ID | DB15598 |
| Brand Names (EU) | Feraccru |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 100.00% |
Approved Indication (EMA)
Feraccru is indicated in adults for the treatment of iron deficiency.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | iron deficiency anemia | 100.00% | DL |
| 2 | deficiency anemia | 100.00% | DL |
| 3 | Plummer-Vinson syndrome | 99.98% | DL |
| 4 | vitamin B12- and folate-independent constitutional megaloblastic anemia | 99.98% | DL |
| 5 | microcytic anemia | 99.93% | DL |
| 6 | IRIDA syndrome | 99.33% | DL |
| 7 | biotin metabolic disease | 98.25% | DL |
| 8 | severe nonproliferative diabetic retinopathy | 98.08% | DL |
| 9 | ariboflavinosis | 97.72% | DL |
| 10 | Keshan disease | 97.22% | DL |
| 11 | non-syndromic esophageal malformation | 97.22% | DL |
| 12 | folic acid deficiency anemia | 97.21% | DL |
| 13 | protein-energy malnutrition | 97.19% | DL |
| 14 | choline deficiency disease | 97.13% | DL |
| 15 | swayback | 97.13% | DL |
| 16 | potassium deficiency | 97.13% | DL |
| 17 | magnesium deficiency | 97.06% | DL |
| 18 | steatitis | 97.04% | DL |
| 19 | vitamin deficiency disorder | 96.92% | DL |
| 20 | hypochromic anemia | 96.85% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.