Gimeracil
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Gimeracil |
| DrugBank ID | DB09257 |
| Brand Names (EU) | Gimeracil |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.89% |
Approved Indication (EMA)
Teysuno is indicated in adults: - for the treatment of advanced gastric cancer when given in combination with cisplatin (see section 5.1). - as monotherapy or in combination with oxaliplatin or irinotecan, with or without bevacizumab, for the treatment of patients with metastatic colorectal cancer for whom it is not possible to continue treatment with another fluoropyrimidine due to hand-foot syndrome or cardiovascular toxicity that developed in the adjuvant or metastatic setting.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | gastric carcinoma | 99.89% | DL |
| 2 | colonic neoplasm | 99.88% | DL |
| 3 | diffuse gastric adenocarcinoma | 99.87% | DL |
| 4 | gastric cancer | 99.82% | DL |
| 5 | cecum villous adenoma | 99.82% | DL |
| 6 | malignant gastric granular cell tumor | 99.82% | DL |
| 7 | lipoma of colon | 99.82% | DL |
| 8 | cecum neuroendocrine tumor G1 | 99.82% | DL |
| 9 | rectosigmoid junction neoplasm | 99.82% | DL |
| 10 | cardia cancer | 99.81% | DL |
| 11 | colonic lymphangioma | 99.81% | DL |
| 12 | colon leiomyoma | 99.81% | DL |
| 13 | gastric lymphoma | 99.81% | DL |
| 14 | cecal disease | 99.81% | DL |
| 15 | pylorus cancer | 99.81% | DL |
| 16 | benign neoplasm of cecum | 99.81% | DL |
| 17 | gastric linitis plastica | 99.80% | DL |
| 18 | malignant gastric germ cell tumor | 99.80% | DL |
| 19 | carcinoma in situ of gastric body | 99.79% | DL |
| 20 | carcinoma in situ of gastric cardia | 99.79% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.