Ketoconazole
| Evidence Level: L5 | Predicted Indications: 61 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Ketoconazole |
| DrugBank ID | DB01026 |
| Brand Names (EU) | Ketoconazole Esteve (previously Ketoconazole HRA) |
| Evidence Level | L5 |
| Predicted Indications | 61 |
| Top Prediction Score | 99.83% |
Approved Indication (EMA)
Ketoconazole Esteve is indicated for the treatment of endogenous Cushing’s syndrome in adults and adolescents above the age of 12 years.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | cutaneous candidiasis | 99.83% | DL |
| 2 | acne (disease) | 99.80% | DL |
| 3 | candidiasis | 99.76% | DL |
| 4 | dermatophytosis of groin and perianal area | 98.38% | DL |
| 5 | pityriasis versicolor | 96.82% | DL |
| 6 | tinea pedis | 95.57% | DL |
| 7 | zinc, elevated plasma | 95.38% | DL |
| 8 | leprosy | 93.11% | DL |
| 9 | vulvovaginal candidiasis | 92.95% | DL |
| 10 | urticaria, aquagenic | 92.69% | DL |
| 11 | punctate epithelial keratoconjunctivitis | 91.43% | DL |
| 12 | tinea corporis | 91.00% | DL |
| 13 | tinea profunda | 90.76% | DL |
| 14 | nail infection | 90.71% | DL |
| 15 | neonatal candidiasis | 90.39% | DL |
| 16 | candida glabrata | 90.39% | DL |
| 17 | congenital candidiasis | 90.39% | DL |
| 18 | demodicidosis of sebaceous gland | 90.10% | DL |
| 19 | candidiasis, invasive | 89.13% | DL |
| 20 | ectothrix infectious disease | 87.80% | DL |
Showing top 20 of 61 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.