Ketorolac
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Ketorolac |
| DrugBank ID | DB00465 |
| Brand Names (EU) | Ketorolac |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.93% |
Approved Indication (EMA)
Omidria is indicated in adults for maintenance of intraoperative mydriasis, prevention of intraoperative miosis and reduction of acute postoperative ocular pain in intraocular lens replacement surgery.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | papillary conjunctivitis | 99.93% | DL |
| 2 | headache disorder | 99.43% | DL |
| 3 | atopic conjunctivitis | 99.41% | DL |
| 4 | rosacea conjunctivitis | 99.40% | DL |
| 5 | trigeminal autonomic cephalalgia | 99.39% | DL |
| 6 | ulcerative proctosigmoiditis | 98.98% | DL |
| 7 | nasopharyngitis | 97.94% | DL |
| 8 | cap polyposis | 97.88% | DL |
| 9 | cutaneous photosensitivity-lethal colitis syndrome | 97.82% | DL |
| 10 | undetermined colitis | 97.74% | DL |
| 11 | allergic urticaria | 97.14% | DL |
| 12 | viral conjunctivitis | 96.14% | DL |
| 13 | vernal conjunctivitis | 95.93% | DL |
| 14 | frozen shoulder | 95.86% | DL |
| 15 | systemic inflammatory disease associated with an acquired peripheral neuropathy | 95.35% | DL |
| 16 | fasciitis (disease) | 95.32% | DL |
| 17 | glossodynia | 95.14% | DL |
| 18 | osteoarthritis susceptibility | 95.12% | DL |
| 19 | coccygodynia | 94.95% | DL |
| 20 | punctate epithelial keratoconjunctivitis | 94.90% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.