Lecanemab
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Lecanemab |
| DrugBank ID | DB14580 |
| Brand Names (EU) | Leqembi |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 98.48% |
Approved Indication (EMA)
Leqembi is indicated for the treatment of adult patients with a clinical diagnosis of mild cognitive impairment and mild dementia due to Alzheimer’s disease (Early Alzheimer’s disease) who are apolipoprotein E 4 (ApoE ε4) non-carriers or heterozygotes with confirmed amyloid pathology (see section 4.4).
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | diabetic cataract | 98.48% | DL |
| 2 | craniostenosis cataract | 98.40% | DL |
| 3 | tetanic cataract | 98.40% | DL |
| 4 | diabetes mellitus type 2 associated cataract | 98.40% | DL |
| 5 | immature cataract | 98.40% | DL |
| 6 | mature cataract | 98.40% | DL |
| 7 | cortical cataract | 98.38% | DL |
| 8 | nuclear senile cataract | 98.38% | DL |
| 9 | senile cataract | 98.32% | DL |
| 10 | diabetic retinopathy | 98.19% | DL |
| 11 | antithrombin deficiency type 2 | 97.94% | DL |
| 12 | severe nonproliferative diabetic retinopathy | 97.93% | DL |
| 13 | factor 5 excess with spontaneous thrombosis | 97.88% | DL |
| 14 | heparin cofactor 2 deficiency | 97.83% | DL |
| 15 | thrombophilia | 97.57% | DL |
| 16 | diffuse gastric adenocarcinoma | 95.75% | DL |
| 17 | hemorrhagic disease of newborn | 95.31% | DL |
| 18 | gastric carcinoma | 95.26% | DL |
| 19 | gastric adenocarcinoma and proximal polyposis of the stomach | 95.06% | DL |
| 20 | bronchitis | 95.03% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.