Lonoctocog Alfa
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Lonoctocog Alfa |
| DrugBank ID | DB13998 |
| Brand Names (EU) | Afstyla |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.85% |
Approved Indication (EMA)
Treatment and prophylaxis of bleeding in patients with haemophilia A (congenital factor VIII deficiency). Afstyla can be used for all age groups.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | pseudo-von Willebrand disease | 99.85% | DL |
| 2 | primary release disorder of platelets | 99.84% | DL |
| 3 | Glanzmann thrombasthenia | 99.76% | DL |
| 4 | Scott syndrome | 99.44% | DL |
| 5 | symptomatic form of hemophilia in female carriers | 99.31% | DL |
| 6 | hemophilia | 99.27% | DL |
| 7 | acquired coagulation factor deficiency | 98.85% | DL |
| 8 | bleeding diathesis due to a collagen receptor defect | 98.71% | DL |
| 9 | hemorrhagic disorder due to a constitutional thrombocytopenia | 98.64% | DL |
| 10 | esophageal varices without bleeding | 98.41% | DL |
| 11 | esophageal varices with bleeding | 98.41% | DL |
| 12 | thrombotic thrombocytopenic purpura | 98.13% | DL |
| 13 | hemophilia A with vascular abnormality | 97.71% | DL |
| 14 | varicose disease | 97.63% | DL |
| 15 | factor XI deficiency | 97.12% | DL |
| 16 | familial apolipoprotein C-II deficiency | 96.51% | DL |
| 17 | fetal and neonatal alloimmune thrombocytopenia | 96.49% | DL |
| 18 | primary immunodeficiency syndrome due to p14 deficiency | 96.11% | DL |
| 19 | flood factor deficiency | 96.03% | DL |
| 20 | hemorrhagic disorder due to a platelet anomaly | 95.75% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.