Oxybutynin
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Oxybutynin |
| DrugBank ID | DB01062 |
| Brand Names (EU) | Kentera (previously Oxybutynin Nicobrand) |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.86% |
Approved Indication (EMA)
Symptomatic treatment of urge incontinence and/or increased urinary frequency and urgency as may occur in adult patients with unstable bladder.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | cauda equina syndrome | 99.86% | DL |
| 2 | overactive bladder (disease) | 99.78% | DL |
| 3 | restless legs syndrome | 99.74% | DL |
| 4 | obsolete neurogenic bladder (disease) | 99.69% | DL |
| 5 | gastroduodenitis | 99.62% | DL |
| 6 | peptic ulcer disease | 99.31% | DL |
| 7 | low compliance bladder | 97.88% | DL |
| 8 | nephrogenic syndrome of inappropriate antidiuresis | 97.46% | DL |
| 9 | insomnia (disease) | 96.90% | DL |
| 10 | attention deficit-hyperactivity disorder | 95.11% | DL |
| 11 | faciodigitogenital syndrome | 94.96% | DL |
| 12 | familial episodic pain syndrome with predominantly upper body involvement | 92.62% | DL |
| 13 | transient tic disorder | 92.45% | DL |
| 14 | migraine disorder | 92.12% | DL |
| 15 | migraine with brainstem aura | 92.02% | DL |
| 16 | sleep disorder, initiating and maintaining sleep | 91.77% | DL |
| 17 | bladder neck obstruction | 91.33% | DL |
| 18 | communication disorder | 90.67% | DL |
| 19 | stereotypic movement disorder | 90.61% | DL |
| 20 | fetal nicotine spectrum disorder | 90.61% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.