Pemigatinib
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Pemigatinib |
| DrugBank ID | DB15102 |
| Brand Names (EU) | Pemazyre |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.71% |
Approved Indication (EMA)
Pemazyre monotherapy is indicated for the treatment of adults with locally advanced or metastatic cholangiocarcinoma with a fibroblast growth factor receptor 2 (FGFR2) fusion or rearrangement that have progressed after at least one prior line of systemic therapy.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | multiple endocrine neoplasia | 99.71% | DL |
| 2 | amenorrhea (disease) | 99.54% | DL |
| 3 | HER2 positive breast carcinoma | 99.49% | DL |
| 4 | cytomegalovirus infection | 99.46% | DL |
| 5 | malignant catarrh | 99.43% | DL |
| 6 | infectious bovine rhinotracheitis | 99.43% | DL |
| 7 | amyotrophic lateral sclerosis | 99.41% | DL |
| 8 | amyotrohpic lateral sclerosis type 22 | 99.27% | DL |
| 9 | amyotrophic lateral sclerosis, susceptibility to | 99.25% | DL |
| 10 | axial spondylometaphyseal dysplasia | 99.25% | DL |
| 11 | Mills syndrome | 99.22% | DL |
| 12 | progesterone-receptor negative breast cancer | 99.18% | DL |
| 13 | progesterone-receptor positive breast cancer | 99.17% | DL |
| 14 | normal breast-like subtype of breast carcinoma | 99.17% | DL |
| 15 | trichomegaly-retina pigmentary degeneration-dwarfism syndrome | 99.17% | DL |
| 16 | breast tumor luminal A or B | 99.15% | DL |
| 17 | lethal arthrogryposis-anterior horn cell disease syndrome | 99.12% | DL |
| 18 | bilateral parasagittal parieto-occipital polymicrogyria | 99.09% | DL |
| 19 | lower motor neuron syndrome with late-adult onset | 99.08% | DL |
| 20 | monomelic amyotrophy | 99.03% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.