Pioglitazone
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Pioglitazone |
| DrugBank ID | DB01132 |
| Brand Names (EU) | Pioglitazone |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.59% |
Approved Indication (EMA)
Incresync is indicated as a second- or third-line treatment in adult patients aged 18 years and older with type-2 diabetes mellitus: as an adjunct to diet and exercise to improve glycaemic control in adult patients (particularly overweight patients) inadequately controlled on pioglitazone alone, and for whom metformin is inappropriate due to contraindications or intolerance; in combination with metformin (i.e. triple combination therapy) as an adjunct to diet and exercise to improve glycaemic c
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | opsismodysplasia | 99.59% | DL |
| 2 | diabetes mellitus (disease) | 99.56% | DL |
| 3 | classic stiff person syndrome | 99.50% | DL |
| 4 | focal stiff limb syndrome | 99.50% | DL |
| 5 | thiamine-responsive dysfunction syndrome | 99.48% | DL |
| 6 | drug-induced localized lipodystrophy | 99.30% | DL |
| 7 | centrifugal lipodystrophy | 99.26% | DL |
| 8 | pressure-induced localized lipoatrophy | 99.24% | DL |
| 9 | idiopathic localized lipodystrophy | 99.19% | DL |
| 10 | pancreatic agenesis | 99.18% | DL |
| 11 | autoimmune oophoritis | 98.06% | DL |
| 12 | type 1 diabetes mellitus | 98.01% | DL |
| 13 | homozygous familial hypercholesterolemia | 85.35% | DL |
| 14 | diabetes mellitus, insulin-dependent, X-linked, susceptibility to | 77.79% | DL |
| 15 | permanent neonatal diabetes mellitus | 69.18% | DL |
| 16 | type 2 diabetes mellitus | 65.47% | DL |
| 17 | cholangiocarcinoma, susceptibility to | 63.71% | DL |
| 18 | hemoglobin C-beta-thalassemia syndrome | 60.18% | DL |
| 19 | obsolete breast fibroadenosis | 59.91% | DL |
| 20 | mitral valve prolapse, myxomatous | 59.91% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.