Prilocaine
| Evidence Level: L5 | Predicted Indications: 51 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Prilocaine |
| DrugBank ID | DB00750 |
| Brand Names (EU) | Fortacin, Prilocaine |
| Evidence Level | L5 |
| Predicted Indications | 51 |
| Top Prediction Score | 99.78% |
Approved Indication (EMA)
Treatment of primary premature ejaculation in adult men.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | papillary conjunctivitis | 99.78% | DL |
| 2 | manic bipolar affective disorder | 99.76% | DL |
| 3 | bronchitis | 99.64% | DL |
| 4 | migraine disorder | 99.42% | DL |
| 5 | neuralgia | 99.34% | DL |
| 6 | migraine with brainstem aura | 99.33% | DL |
| 7 | atopic eczema | 99.31% | DL |
| 8 | allergic asthma | 99.29% | DL |
| 9 | rhinitis | 99.28% | DL |
| 10 | rosacea conjunctivitis | 99.24% | DL |
| 11 | intrinsic asthma | 99.16% | DL |
| 12 | nasal cavity disease | 99.06% | DL |
| 13 | pharyngitis | 99.00% | DL |
| 14 | transient ischemic attack (disease) | 98.99% | DL |
| 15 | conjunctivitis | 98.97% | DL |
| 16 | cauda equina syndrome | 98.83% | DL |
| 17 | acute laryngopharyngitis | 98.81% | DL |
| 18 | atopic conjunctivitis | 98.80% | DL |
| 19 | blepharoconjunctivitis | 98.73% | DL |
| 20 | Tourette syndrome | 98.71% | DL |
Showing top 20 of 51 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.