Prucalopride Succinate
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Prucalopride Succinate |
| DrugBank ID | DB06480 |
| Brand Names (EU) | Resolor |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.82% |
Approved Indication (EMA)
Resolor is indicated for symptomatic treatment of chronic constipation in adults in whom laxatives fail to provide adequate relief.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | hypoalphalipoproteinemia | 99.82% | DL |
| 2 | homozygous familial hypercholesterolemia | 99.67% | DL |
| 3 | duodenal ulcer (disease) | 99.65% | DL |
| 4 | oral candidiasis | 99.64% | DL |
| 5 | obsolete familial combined hyperlipidemia | 99.62% | DL |
| 6 | amyloidosis (disease) | 99.62% | DL |
| 7 | strongyloidiasis | 99.60% | DL |
| 8 | HIV infectious disease | 99.60% | DL |
| 9 | primary amyloidosis | 99.56% | DL |
| 10 | acquired amyloid peripheral neuropathy | 99.55% | DL |
| 11 | dermis disease | 99.54% | DL |
| 12 | multiple endocrine neoplasia | 99.52% | DL |
| 13 | duodenal obstruction | 99.51% | DL |
| 14 | nodular cutaneous amyloidosis | 99.51% | DL |
| 15 | amyloidosis cutis dyschromia | 99.51% | DL |
| 16 | macular amyloidosis | 99.51% | DL |
| 17 | commissural lip fistula | 99.50% | DL |
| 18 | osteoradionecrosis of the mandible | 99.50% | DL |
| 19 | oral leukoedema | 99.50% | DL |
| 20 | burning mouth syndrome | 99.50% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.