Sevelamer
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Sevelamer |
| DrugBank ID | DB00658 |
| Brand Names (EU) | Renagel |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 92.46% |
Approved Indication (EMA)
Renagel is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis. Renagel should be used within the context of a multiple therapeutic approach, which could include calcium supplements, 1,25 - dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | breast fibrocystic disease | 92.46% | DL |
| 2 | blunt duct adenosis of breast | 89.91% | DL |
| 3 | apocrine adenosis of breast | 89.91% | DL |
| 4 | benign mammary dysplasia | 88.89% | DL |
| 5 | HIV infectious disease | 87.16% | DL |
| 6 | AIDS | 86.40% | DL |
| 7 | breast abscess | 83.58% | DL |
| 8 | fat necrosis of breast | 83.58% | DL |
| 9 | lactation disease | 83.42% | DL |
| 10 | neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter | 83.18% | DL |
| 11 | simian immunodeficiency virus infection | 82.81% | DL |
| 12 | feline acquired immunodeficiency syndrome | 82.81% | DL |
| 13 | breast adenosis | 82.21% | DL |
| 14 | congestive heart failure | 80.22% | DL |
| 15 | AIDS related complex | 79.81% | DL |
| 16 | congenital human immunodeficiency virus | 79.81% | DL |
| 17 | acute pulmonary heart disease | 79.40% | DL |
| 18 | ulceration of vulva | 79.27% | DL |
| 19 | vulvar neoplasm | 78.93% | DL |
| 20 | vulvitis | 77.84% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.