Temoporfin
| Evidence Level: L5 | Predicted Indications: 52 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Temoporfin |
| DrugBank ID | DB11630 |
| Brand Names (EU) | Foscan |
| Evidence Level | L5 |
| Predicted Indications | 52 |
| Top Prediction Score | 99.78% |
Approved Indication (EMA)
Foscan is indicated for the palliative treatment of patients with advanced head and neck squamous cell carcinoma failing prior therapies and unsuitable for radiotherapy, surgery or systemic chemotherapy.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | nasopharyngeal teratoma | 99.78% | DL |
| 2 | odontogenic cyst | 99.77% | DL |
| 3 | pre-malignant neoplasm | 99.77% | DL |
| 4 | epiglottis neoplasm | 99.76% | DL |
| 5 | tumor of testis and paratestis | 99.76% | DL |
| 6 | cystic neoplasm | 99.76% | DL |
| 7 | benign neoplasm of floor of mouth | 99.76% | DL |
| 8 | benign neoplasm of tongue | 99.76% | DL |
| 9 | benign neoplasm of hypopharynx | 99.76% | DL |
| 10 | cervical neuroblastoma | 99.76% | DL |
| 11 | thyroglossal duct cyst | 99.76% | DL |
| 12 | non-seminomatous lesion | 99.76% | DL |
| 13 | ductal or ductular proliferation | 99.76% | DL |
| 14 | chondroid hamartoma | 99.76% | DL |
| 15 | bronchial adenomas/carcinoids childhood | 99.76% | DL |
| 16 | schwannoma of jugular foramen | 99.76% | DL |
| 17 | nasal cavity inverting papilloma | 99.76% | DL |
| 18 | inner ear neoplasm | 99.76% | DL |
| 19 | benign neoplasm of buccal mucosa | 99.75% | DL |
| 20 | jugular foramen meningioma | 99.75% | DL |
Showing top 20 of 52 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.