Tiratricol
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Tiratricol |
| DrugBank ID | DB03604 |
| Brand Names (EU) | Emcitate |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 93.28% |
Approved Indication (EMA)
Emcitate is indicated for the treatment of peripheral thyrotoxicosis in patients with monocarboxylate transporter 8 (MCT8) deficiency (Allan-Herndon-Dudley Syndrome), from birth.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | migraine with brainstem aura | 93.28% | DL |
| 2 | migraine disorder | 92.31% | DL |
| 3 | seborrheic dermatitis | 80.59% | DL |
| 4 | amenorrhea (disease) | 80.14% | DL |
| 5 | polyp of vocal cord | 59.14% | DL |
| 6 | polyp of middle ear | 58.83% | DL |
| 7 | uterine polyp | 58.80% | DL |
| 8 | ocular tuberculosis | 58.59% | DL |
| 9 | polyp of frontal sinus | 58.11% | DL |
| 10 | polyp of ureter | 58.08% | DL |
| 11 | polyp of external auditory canal | 57.65% | DL |
| 12 | polyp of vulva | 57.32% | DL |
| 13 | epulis | 57.23% | DL |
| 14 | sunburn | 57.04% | DL |
| 15 | fibroepithelial polyp | 56.78% | DL |
| 16 | acne (disease) | 56.56% | DL |
| 17 | obsolete pathologic fracture | 56.39% | DL |
| 18 | arteriosclerosis obliterans | 56.18% | DL |
| 19 | obsolete functional visual loss | 56.18% | DL |
| 20 | guttate psoriasis | 56.14% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.