Vemurafenib
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Vemurafenib |
| DrugBank ID | DB08881 |
| Brand Names (EU) | Zelboraf |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 97.65% |
Approved Indication (EMA)
Vemurafenib is indicated in monotherapy for the treatment of adult patients with BRAF-V600-mutation-positive unresectable or metastatic melanoma.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | HIV infectious disease | 97.65% | DL |
| 2 | neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter | 96.73% | DL |
| 3 | simian immunodeficiency virus infection | 96.56% | DL |
| 4 | feline acquired immunodeficiency syndrome | 96.56% | DL |
| 5 | acute intermittent porphyria | 96.21% | DL |
| 6 | collagenopathy | 95.32% | DL |
| 7 | paratenonitis | 95.25% | DL |
| 8 | female breast carcinoma | 95.15% | DL |
| 9 | calcific tendinitis | 95.13% | DL |
| 10 | lymphocytic hypereosinophilic syndrome | 95.00% | DL |
| 11 | Plasmodium falciparum malaria | 94.78% | DL |
| 12 | homozygous familial hypercholesterolemia | 94.58% | DL |
| 13 | gout | 94.30% | DL |
| 14 | obsolete familial combined hyperlipidemia | 94.29% | DL |
| 15 | dermatofibrosarcoma protuberans | 93.80% | DL |
| 16 | myositis | 93.64% | DL |
| 17 | headache disorder | 93.47% | DL |
| 18 | rheumatoid arthritis | 93.43% | DL |
| 19 | trigeminal autonomic cephalalgia | 93.26% | DL |
| 20 | arteriosclerosis disorder | 91.93% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.