Ziconotide
| Evidence Level: L5 | Predicted Indications: 50 |
Quick Overview
| Item | Value |
|---|---|
| Drug Name | Ziconotide |
| DrugBank ID | DB06283 |
| Brand Names (EU) | Prialt |
| Evidence Level | L5 |
| Predicted Indications | 50 |
| Top Prediction Score | 99.92% |
Approved Indication (EMA)
Ziconotide is indicated for the treatment of severe, chronic pain in patients who require intrathecal (IT) analgesia.
Predicted New Indications
TxGNN model predictions for potential drug repurposing:
| Rank | Indication | Score | Source |
|---|---|---|---|
| 1 | migraine disorder | 99.92% | DL |
| 2 | migraine with brainstem aura | 99.88% | DL |
| 3 | cauda equina syndrome | 99.87% | DL |
| 4 | obesity disorder | 99.67% | DL |
| 5 | transient ischemic attack (disease) | 99.65% | DL |
| 6 | open-angle glaucoma | 99.64% | DL |
| 7 | obsolete neurogenic bladder (disease) | 99.63% | DL |
| 8 | migraine with or without aura, susceptibility to | 99.62% | DL |
| 9 | primary hereditary glaucoma | 99.59% | DL |
| 10 | preeclampsia | 99.58% | DL |
| 11 | atrophoderma vermiculata | 99.49% | DL |
| 12 | acne (disease) | 99.49% | DL |
| 13 | hypervitaminosis | 99.45% | DL |
| 14 | ulerythema ophryogenesis | 99.41% | DL |
| 15 | monogenic obesity | 99.41% | DL |
| 16 | pulmonary hypertension | 99.31% | DL |
| 17 | obsolete hypertelorism (disease) | 99.30% | DL |
| 18 | proximal 16p11.2 microdeletion syndrome | 99.27% | DL |
| 19 | hypotrichosis simplex of the scalp | 99.24% | DL |
| 20 | congenital hypotrichosis milia | 99.19% | DL |
Showing top 20 of 50 predictions.
About TxGNN Predictions
Prediction Sources
| Source | Description |
|---|---|
| KG | Knowledge Graph - Network topology-based associations |
| DL | Deep Learning - Neural network score prediction |
Evidence Levels
| Level | Definition |
|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews |
| L2 | Single RCT or multiple Phase 2 trials |
| L3 | Observational studies / Large case series |
| L4 | Preclinical / Mechanistic / Case reports |
| L5 | AI prediction only (current) |
Clinical Validation Needed
Research Use Only: These predictions are computational hypotheses that require clinical validation. They should NOT be used for clinical decision-making.
Next Steps for Validation
- Literature Review: Search PubMed for existing evidence
- Clinical Trial Search: Check ClinicalTrials.gov for ongoing studies
- Mechanistic Analysis: Evaluate biological plausibility
- Preclinical Studies: Conduct in vitro/in vivo validation
- Clinical Trials: Design and conduct human studies
Data Access
- FHIR API:
/fhir/ClinicalUseDefinition/ - CSV Download: All Predictions
- GitHub: yao-care/EuTxGNN
Citation
If using this data, please cite:
@article{huang2023txgnn,
title={A foundation model for clinician-centered drug repurposing},
author={Huang, Kexin and others},
journal={Nature Medicine},
year={2023},
doi={10.1038/s41591-023-02233-x}
}
Disclaimer: This report is for research purposes only and does not constitute medical advice. Drug repurposing predictions require rigorous clinical validation before any therapeutic application.