High Evidence Level Drugs
Candidates with strong clinical trial evidence for priority evaluation
Evidence Standards
| Level | Definition | Clinical Significance |
|---|---|---|
| L1 | Multiple Phase 3 RCTs / Systematic Reviews | Strong support, consider clinical use |
| L2 | Single RCT or multiple Phase 2 trials | Moderate support, design validation trial |
Current Status
Note: Evidence level curation is in progress. Currently, all predictions are L5 (AI prediction only). High evidence candidates will be added as clinical evidence is validated.
Criteria for L1-L2 Classification
L1 Requirements
- ≥2 Phase 3 randomized controlled trials
- OR systematic review/meta-analysis
- Consistent positive results
- Published in peer-reviewed journals
L2 Requirements
- 1 Phase 3 RCT with positive results
- OR ≥2 Phase 2 trials
- Published in peer-reviewed journals
How to Contribute
If you have evidence for any prediction, please:
- Open an issue on GitHub
- Provide PubMed ID or clinical trial identifier
- We will review and update evidence levels