Medium Evidence Level Drugs

Candidates with preliminary evidence requiring further validation

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Evidence Standards

Level	Definition	Clinical Significance
L3	Observational studies / Large case series	Preliminary evidence, needs RCT
L4	Preclinical / Mechanistic / Case reports	Mechanism reasonable, lacks clinical validation

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Current Status

Note: Evidence level curation is in progress. Currently, all predictions are L5 (AI prediction only). Medium evidence candidates will be added as supporting evidence is identified.

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Criteria for L3-L4 Classification

L3 Requirements

• Cohort or case-control study
• OR large case series (≥50 patients)
• Published results with quantitative outcomes

L4 Requirements

• In vitro or animal studies showing efficacy
• OR mechanistic rationale with supporting data
• OR case reports (< 10 patients)

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Potential L3-L4 Candidates

Based on existing literature, these predictions may have supporting evidence:

Drug	Indication	Potential Evidence
Under review	Under review	Under review

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How to Contribute

Help us identify evidence for predictions:

1. Check PubMed for relevant studies
2. Report findings via GitHub Issues
3. Include study type and results

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Related Pages

• High Evidence (L1-L2)
• AI Predictions (L5)
• Full Drug List