User Guide
How to read and use EuTxGNN reports
Quick Start
1. Find a Drug of Interest
- Use the search function in the navigation
- Or browse the Drug List
- Or filter by Evidence Level
2. Check Evidence Level
Each drug-indication pair has an evidence level (L1-L5):
| Level | Meaning | Confidence |
|---|---|---|
| L1 | Multiple large RCTs support | ⭐⭐⭐⭐⭐ |
| L2 | Single RCT or multiple Phase 2 | ⭐⭐⭐⭐ |
| L3 | Observational studies | ⭐⭐⭐ |
| L4 | Preclinical/Mechanistic research | ⭐⭐ |
| L5 | AI prediction only | ⭐ |
3. Review the Evidence
Each report contains detailed analysis and supporting data.
Understanding Predictions
Prediction Score
The TxGNN score (0-1) indicates model confidence:
| Score Range | Interpretation |
|---|---|
| 0.99+ | Very high confidence |
| 0.90-0.99 | High confidence |
| 0.70-0.90 | Moderate confidence |
| < 0.70 | Lower confidence |
Source Types
| Source | Description |
|---|---|
| TxGNN Knowledge Graph | Based on network topology |
| TxGNN Deep Learning | Based on neural network |
FHIR Integration
For Developers
EuTxGNN provides FHIR R4 compliant APIs:
# Get metadata
curl https://eutxgnn.yao.care/fhir/metadata
# Get specific drug
curl https://eutxgnn.yao.care/fhir/MedicationKnowledge/metformin.json
For SMART Apps
Launch URL: https://eutxgnn.yao.care/smart/launch.html
Required scopes:
patient/MedicationRequest.readpatient/Patient.read
Data Export
CSV Format
Download predictions in CSV format from the Downloads page.
JSON Format
FHIR resources are available in JSON format via the API.
Limitations to Consider
- Research Only: Not for clinical decision-making
- Validation Required: All predictions need clinical validation
- Coverage: Limited to EMA-approved drugs with DrugBank mappings
- Evidence Levels: Currently all L5 (AI prediction only)
Frequently Asked Questions
What is drug repurposing?
Finding new therapeutic uses for existing approved drugs.
How accurate are the predictions?
TxGNN achieves high performance in validation studies, but predictions should be validated clinically.
Can I use this for clinical decisions?
No. This is for research purposes only.
How often is data updated?
Predictions are based on EMA data as of 2026. Updates may be made periodically.
Contact
For questions or feedback, please open an issue on GitHub.