Project Introduction

EuTxGNN: AI-Powered Drug Repurposing for Europe

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What is EuTxGNN?

EuTxGNN (European TxGNN) is a drug repurposing prediction platform that uses the Harvard TxGNN model to identify potential new therapeutic uses for EMA-approved medications.

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Mission

To accelerate drug repurposing research by:

1. Predicting new therapeutic uses using AI
2. Validating predictions with clinical evidence
3. Sharing results via FHIR-compliant APIs
4. Enabling integration with healthcare systems

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Key Features

AI-Powered Predictions

• TxGNN Model: Graph neural network trained on biomedical knowledge
• 642 Drugs: EMA-approved medications analyzed
• 32,368 Predictions: Potential new therapeutic uses

Evidence Integration

• ClinicalTrials.gov: Active clinical trial data
• PubMed: Scientific literature evidence
• DrugBank: Drug interaction data

Healthcare Integration

• FHIR R4: Standardized healthcare data
• SMART on FHIR: EHR-integrated application
• Open API: Free research access

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How It Works

┌─────────────────┐
│   EMA Drugs     │
│   (642 drugs)   │
└────────┬────────┘
         ↓
┌─────────────────┐
│   TxGNN Model   │
│   (Knowledge    │
│    Graph + GNN) │
└────────┬────────┘
         ↓
┌─────────────────┐
│   Predictions   │
│  (32,368 pairs) │
└────────┬────────┘
         ↓
┌─────────────────┐
│   Evidence      │
│   Collection    │
└────────┬────────┘
         ↓
┌─────────────────┐
│   FHIR API +    │
│   Drug Reports  │
└─────────────────┘

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Evidence Levels

Level	Description	Count
L1	Multiple RCTs	12
L2	Single RCT	28
L3	Observational	45
L4	Preclinical	89
L5	AI Only	468

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Use Cases

Researchers

• Identify repurposing candidates for specific diseases
• Access FHIR-formatted prediction data
• Download bulk datasets for analysis

Clinicians

• Review repurposing evidence for patient medications
• Access via SMART on FHIR in EHR
• Explore potential off-label uses

Healthcare IT

• Integrate predictions into clinical systems
• Build custom applications using FHIR API
• Implement clinical decision support

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Related Projects

Project	Region	Focus
TwTxGNN	Taiwan	TFDA drugs
EuTxGNN	Europe	EMA drugs

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Getting Started

1. Browse: Drug Reports
2. Search: Homepage Search
3. API: FHIR Specification
4. Integrate: SMART on FHIR

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Citation

@misc{eutxgnn2026,
  title={EuTxGNN: Drug Repurposing Predictions for EMA-Approved Medicines},
  author={yao.care},
  year={2026},
  url={https://eutxgnn.yao.care}
}

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Contact

• GitHub: yao-care/EuTxGNN
• Issues: Report a bug